Renin and aldosterone response in human newborns to acute change in blood volume.

Renin and aldosterone response in human newborns to acute blood volume change.

Relative influence of acute sodium and volume depletion on aldosterone secretion in nephrectomized man.

Plasma aldosterone concentration can increase in anephric man during hemodialysis despite the lack of kidneys to produce renin. Because the metabolic clearance rate of aldosterone does not change during hemodialysis, aldosterone secretion must increase in response to sodium depletion, volume depletion, or both. This study was designed to determine the relative influence of sodium and volume dep...

Effect of ATP-Dependent K+ Channel Openers and Blockers on Serum Concentration of Aldosterone in Rats

There are many reports for involvement of ATP-sensitive potassium channels in pancreatic, cardiac and vascular smooth muscle cells. This study examined the effect of single doses of K+ channel openers diazoxide, minoxidil and K+ channel blockers chlorpropamide, glibenclamide on serum concentration of aldosterone in male rats. Blood samples were obtained 60 minutes after drug treatment and serum...

CALL FOR PAPERS Control Mechanisms of Renin Synthesis and Release: A 21st Century Perspective Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total body sodium

Kjolby M, Bie P. Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total body sodium. Am J Physiol Regul Integr Comp Physiol 294: R17–R25, 2008. First published November 7, 2007; doi:10.1152/ajpregu.00435.2007.—Responses to acute sodium loading depend on the load and on the level of chronic sodium intake. To ...

Renin and Aldosterone Secretion in Man

In six normal volunteers maintained on a constant dietary intake, serial studies were made of plasma renin activity, blood volume, aldosterone secretion and sodium balance, first following dietary and diuretic-induced depletion of sodium and blood volume, then following a period of sodium repletion during a maintained reduction in blood volume, and finally after blood volume repletion. In the f...